For decades, most birth control methods have been targeted toward women. From pills and IUDs to patches and implants, women have carried much of the responsibility for preventing pregnancy. But that may soon change. Enter Nestorone/Testosterone gel—a promising new male birth control that could offer a safe, reversible, and easy-to-use option for men. But how does it work? Is it effective? And what are the pros and cons?
Let’s explore the science behind this gel, what researchers are saying, and what it could mean for the future of family planning.
What Is Nestorone/Testosterone Gel?
Nestorone/Testosterone gel (sometimes referred to as NES/T) is a hormonal contraceptive designed specifically for men. It’s a clear, odorless gel applied daily to the shoulders and upper arms. The combination of Nestorone (a progestin) and Testosterone works to temporarily reduce sperm production without affecting a man’s sex drive or overall testosterone levels.
The gel is currently in the advanced stages of clinical trials, led by the National Institutes of Health (NIH) and the Population Council.
How Does It Work?
The active ingredient, Nestorone, signals the brain to reduce the production of follicle-stimulating hormone (FSH) and luteinizing hormone (LH)—two hormones essential for sperm production. Meanwhile, the added testosterone maintains healthy levels of the male hormone in the bloodstream.
This dual-hormone approach:
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Suppresses sperm production effectively
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Maintains libido, energy, and muscle mass
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Offers a reversible form of birth control (sperm count returns to normal after stopping use)
Pros of Nestorone/Testosterone Gel
1. Non-Invasive and Easy to Use
Unlike condoms or vasectomies, this method is as simple as applying lotion. Just rub it on your skin once a day.
2. Reversible
Unlike permanent methods like vasectomy, sperm production returns to normal a few months after stopping the gel.
3. Shared Responsibility
This gel gives men more control over contraception and allows couples to better share the responsibility of preventing pregnancy.
4. Maintains Hormonal Balance
Thanks to the added testosterone, users won’t experience common side effects of low testosterone, such as mood swings, low energy, or reduced sex drive.
5. High Compliance
In clinical trials, most men reported that the gel was easy to use, and many said they would recommend it to others.
Cons of Nestorone/Testosterone Gel
1. Daily Commitment
Like the birth control pill for women, the gel must be applied every day. Missing applications could reduce its effectiveness.
2. Potential Side Effects
Reported side effects in trials include:
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Mild acne
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Changes in mood
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Headaches
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Slight weight gain
However, side effects have generally been mild and manageable.
3. Skin Contact Risk
After applying the gel, users need to wait a few hours before skin-to-skin contact with others to avoid transferring the hormone—especially important if you live with children or pregnant women.
4. Not Yet Available
The gel is still in clinical trials and not yet available on the market. Widespread availability is likely still a few years away.Is It Effective?
Is It Effective?
According to preliminary results from Phase 2 trials, the gel has been shown to lower sperm counts to levels that effectively prevent pregnancy in most men. It may take 8 to 12 weeks of daily use for the sperm count to drop to the desired level.
Researchers say the failure rate is comparable to hormonal birth control methods used by women.
What Do Men Think About Nestorone/Testosterone Gel?
Feedback from study participants has been overwhelmingly positive. Many men said they felt empowered and appreciated having an active role in preventing pregnancy. In one study, 80% of users said they would be willing to use the gel if it became available.
Couples in long-term relationships have also expressed strong support, especially those looking for a reliable alternative to female hormonal birth control.
The Future of Male Birth Control
Nestorone/Testosterone gel is not just another product—it represents a shift in the conversation around reproductive health. Until now, men have had limited birth control choices: condoms or vasectomy. This gel opens the door for new possibilities.
While we wait for FDA approval and more research, the future looks promising. The success of this gel could pave the way for even more male contraceptive options in the years to come.
Final Thoughts
Contraceptive responsibility shouldn’t fall solely on women. Nestorone/Testosterone gel offers a new, empowering option for men who want to take control of their reproductive choices.
Although it’s still in clinical testing, the early results are encouraging. It’s safe, easy to use, and reversible—three big checkmarks for any new birth control method.
As science moves forward, this gel could soon become a game-changer in family planning.
