Hepatitis
What is Hepatitis? Acute hepatitis describes numerous conditions that involve sudden inflammation or damage to the …
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Genetic Disorders
Alkaptonuria
What is Alkaptonuria? Alkaptonuria is a very rare genetic disorder that occurs due to a shortage …
Congenital Vertical Talus
What is Congenital Vertical Talus? Congenital vertical talus is a condition where the foot is angled …
Albinism
What is Albinism? Albinism, which means “white” in Latin, refers to a collection of hereditary conditions …
Alpers-Huttenlocher Syndrome
What is Alpers-Huttenlocher Syndrome? Alpers-Huttenlocher syndrome (AHS) is a disease that you can inherit from your …
Allgrove Syndrome (3A syndrome (AAA))
What is Allgrove Syndrome (3A syndrome (AAA))? Allgrove syndrome, also known as 3A syndrome (AAA), was …
Congenital Adrenal Hyperplasia
What is Congenital Adrenal Hyperplasia? Congenital adrenal hyperplia (CAH) is a genetic disease that occurs when …
Ciliary Dysfunction (Genetic Disorder of the Hair Cells that Clear the Airways Causing Chronic Ear, Lung, and Sinus Disease)
What is Ciliary Dysfunction (Genetic Disorder of the Hair Cells that Clear the Airways Causing Chronic …
Cockayne Syndrome (Genetic Syndrome Causing Sensitivity to Ultraviolet Light, Dwarfism, Intelectual Disabilities, and Skeletal Anomalies)
What is Cockayne Syndrome (Genetic Syndrome Causing Sensitivity to Ultraviolet Light, Dwarfism, Intelectual Disabilities, and Skeletal …
Anorectal Malformations (Imperforate Anus)
What is Anorectal Malformations (Imperforate Anus)? Anorectal malformation, often referred to as imperforate anus, is a …
What is RSV? Symptoms, Prevention, and Treatments
Respiratory Syncytial Virus (RSV) is a common virus that infects the respiratory tract, primarily affecting the …
Cystinosis
What is Cystinosis? Cystinosis is a rare genetic disorder that results from changes or mutations in …
Necrolytic Acral Erythema
What is Necrolytic Acral Erythema? Necrolytic acral erythema is a rare skin condition largely linked to …
![Fig 1 (a) Clinical Picture of Acrokeratoelastoidosis (AKE) of Costa involving the feet. Skin-colored keratotic papules clustered linearly along the medial margins of the feet, with easily appreciable umblication (white arrow) in many lesions; (b) Clinical Picture of Acrokeratoelastoidosis (AKE) of Costa involving the hands revealing similar lesions involving the dorsa as well (inverse papular acrokeratosis); (c) Dermoscopic image demonstrating focal clusters of pale-to-yellowish colored papules with slight umbilication (black arrows) in a few of them, interspersed with pale yellow-colored structureless areas [Escope videodermoscope, 20X, polarized); (d) Histopathology revealing hyperkeratosis, hypergranulosus, mild acanthosis, dermal collagen homogenization and elastorrhesis (fewer and fragmented elastic fibres) [Hematoxylin & Eosin, 400X]; and (e) Histopathology stained with Verhoeff’s-Van Gieson (VVG) stain, revealing elastorrhexis (black arrow) more clearly [VVG, 400X].](data:image/svg+xml;nitro-empty-id=MTMwMzoxNDc2-1;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMzk1IDI0MCIgd2lkdGg9IjM5NSIgaGVpZ2h0PSIyNDAiIHhtbG5zPSJodHRwOi8vd3d3LnczLm9yZy8yMDAwL3N2ZyI+PC9zdmc+)
Acrokeratoelastoidosis (Genetic Skin Lesions)
What is Acrokeratoelastoidosis (Genetic Skin Lesions)? Acrokeratoelastoidosis (AKE), also known as inverse papular acrokeratosis, is a …